Leprosy is a chronic disease caused by a bacillus, Mycobacterium leprae (M. leprae).
The M. leprae organism multiplies very slowly and the incubation period of the disease varies from months to 30 years with an average of 4 years for tuberculoid leprosy and 10 years for lepromatous leprosy.
Leprosy mainly affects the skin and peripheral nerves. If left untreated, it can lead to progressive and permanent damage of nerves, leading to loss of sensation and sweating in the extremities and paralysis of muscles in the hands, feet and face.
The disease is classified according to the extent of disease.
The usual clinical presentation varies between the two polar forms, lepromatous and tuberculoid leprosy. Host immune response determines the clinical features.
In lepromatous leprosy, there is a high bacillary load and more severe disseminated disease. Nodules, papules, macules and diffuse infiltrations are bilaterally symmetrical and usually numerous and extensive. The skin lesions may not be anaesthetic or hypopigmented. The nasal mucosa may be involved, and iritis and keratitis can occur.
In tuberculoid leprosy there is a lower bacillary load, skin lesions are single or few, sharply demarcated, anaesthetic or hyperaesthetic and bilaterally asymmetrical; peripheral nerve involvement tends to be severe.
The exact mechanism of transmission is not well understood, although person to person spread via nasal droplets is believed to be the main route. Large amounts of M leprae organisms have been found in the nasal secretions of people with untreated lepromatous leprosy.
Leprosy is one of the least infectious diseases, because:
The overwhelming majority of people who are exposed to leprosy do not develop the disease. Those at greatest risk are people who have lived in a household-like setting with a person with leprosy for more than a month. Extended close contact is required for people to be exposed to leprosy.
Minimising the potential for exposure to leprosy is an important prevention strategy. Prevention strategies for Leprosy include:
The diagnosis of leprosy is based primarily on demonstrated clinical features and can be confirmed by skin smears, skin biopsy or nerve biopsy. A complete history and physical examination including skin examination, nerve palpation and assessment, eye examination and an assessment for deformity, and disability in addition to laboratory tests are essential to diagnose leprosy.
It is important to know that leprosy can be cured. Medication should be administered under the supervision of a specialist physician. Multi drug therapy is used to effectively treat leprosy.Current treatment regimens consist of 6 months of daily dapsone and monthly rifampicin for paucibacillary leprosy, and daily dapsone and clofazamine and monthly rifampicin for multibacillary leprosy for a 24 month period to reduce the risk of relapse. Specialist advice should be sought for detailed treatment regimens.
Laboratories and doctors must notify cases of leprosy to their local Public Health Unit. Individual cases are managed by specialised physicians. Public health action focuses on effective treatment of individuals with multi drug therapy, follow up, counselling and education of contacts.
For further information please call your local Public Health Unit on 1300 066 055