​NSW Health is preparing to introduce the new Medicines, Poisons and Therapeutic Goods Act 2022 and its sup​porting Regulation, which are expected to commence once approved (date to be advised).

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Applications for approval

Use SafeScript NSW to apply for approval to prescribe Schedule 8:

  • medicines under the NSW Opioid Treatment Program (OTP)
  • psychostimulant medicines
  • pain management medicines
  • benzodiazepines
  • esketamine and ketamine (for treatment resistant depression).

For all PDF application forms click below.

PDF application forms
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Opioid treatment in NSW

The NSW Opioid Treatment Program (OTP) seeks to reduce the social, economic and health harms associated with opioid use.

More information

SafeScript NSW

Use SafeScript NSW to:

  • access real-time information about a patient's prescription and dispensing history for certain high-risk medicines
  • submit applications for approval to prescribe and/or supply certain Schedule 8 medicines.
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Legislative requirements

Access guides and information on legal requirements for the prescribing and supply of Schedule 8 medicines and other restricted substances.

More information
Current as at: Monday 13 October 2025
Contact page owner: Pharmaceutical Services