​​​SafeScript NSW can now be used to apply and receive approvals online for Schedule 8 medicines under the NSW Opioid Treatment Program.  SafeScript NSW allows you to monitor and track your approvals in real time and see your patient's approval history.  

The NSW Opioid Treatment Program (OTP) seeks to reduce the social, economic and health harms associated with opioid use. The OTP delivers pharmacotherapy and associated services to opioid dependent patients in NSW.

To enrol a patient on the NSW OTP authorisation from the NSW Ministry of Health is required.

Refer to NSW clinical guidelines: Treatment of opioid dependence for further information. Information is also available on depot buprenorphine.

Updated Centre for Alcohol and other Drugs (CAOD) guidelines are available to guide practitioner on using micro-dosing or bridging transfer techniques.

OTP medicines are part of the  Section 100 Highly Specialised Drugs (HSD) Program (Community Access) arrangements. For further information, including FAQs and example PBS scripts see Opioid Treatment Program – Transition to Section 100 Highly Specialised Drugs Program.


Specialist advisory line

Contact NSW Drug & Alcohol Specialist Advisory Services (DASAS) on (02) 8382 1006 in Sydney metropolitan areas or 1800 023 687 in NSW regional/rural areas for clinical advice on the diagnosis and clinical management of patients with alcohol or other drug related problems.


From 13 November 2023 SafeScript NSW  can be used to submit and manage applications for authority to prescribe or supply Schedule 8 medicines under the OTP. SafeScript NSW allows prescribers to apply online to enrol a patient on the NSW OTP and add and update dosing points allowing health practitioners involved in patient care to have clarity on where the patient is being dosed.  

If you are unable to register for SafeScript NSW you may submit a completed application form via email to MOH-OTP@health.nsw.gov.au, or via fax to the Pharmaceutical Services Unit at (02) 9424 5885

Notifications and other information

Interstate transfers​

Interstate prescribers who wish to temporarily transfer a patient to the NSW OTP are required to complete and submit an Application for Temporary Interstate Transfer to NSW Opioid Treatment Program.

For information about permanently transferring an OTP patient​ to NSW or temporarily transferring a NSW OTP patient to another State/Territory refer to the NSW Opioid Treatment Program.

Non-accredited prescribers

Medical and nurse practitioners must successfully complete the Fundamentals of Training and Opioid Treatment Accreditation Course (OTAC) to become an accredited OTP prescriber in NSW.

A NSW medical practitioner who has not received accreditation as a NSW OTP prescriber may be authorised by the Ministry of Health to manage up to 30 patients including:

  • maximum of 10 patients treated with methadone who are referred by an accredited OTP prescriber
  • maximum of 20 patients treated with buprenorphine or buprenorphine-naloxone, who may be inducted by a non-accredited prescriber or referred by an accredited OTP prescriber.

Non-accredited prescribers are encouraged to complete the free online F​​undamentals Training course to ensure they understand the requirements for prescribing opioid pharmacotherapy for patients.

Authorisation to prescribe or supply methadone or buprenorphine (including buprenorphine-naloxone) must be granted by the NSW Ministry of Health before a prescription may be issued to commence treatment.

Current as at: Tuesday 20 February 2024
Contact page owner: Pharmaceutical Services